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Alterations of DNA methylation by glutathione depletion - ScienceDirect

Peroxynitrite, a powerful oxidant and nitrating species, which causes nitrotyrosine protein adducts in mitochondria, triggers the mitochondrial permeability transition pore (MPTP) opening [31] and cell necrosis [32] (Figure 1)

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Many ROS scavenging pathways have been well studied against stress responses